Genetic testing for colorectal cancer

Target therapy is a medicine aimed at certain molecules/proteins on the surface of cancer cells or inside, resulting in prevention of the growth and spread of cancer cells without a damage to healthy cells.

One target doesn’t fit all types of cancer. Genetic testing are used to clear up the most effective therapy. Plenty of clinical studies are being conducted constantly.

About the genetic testing for colorectal cancer

An NGS-based analysis that comprises genes focused on the clinical use of approved targeted medicine for colorectal cancer and agents from prospective clinical trials .

Changes in these genes result in tumor development and are used as diagnostic, prognostic, and predictive markers of cancer.

The assay identifies:

1. hotspots (SNV/indels)
2. copy number variations (CNV)
3. chromosomal aberrations (gene fusions)

Indications for genetic testing:

Colorectal cancer patients to:

1. Choose of cancer therapy
2. Monitor and adjust therapy in case of disease relapse

To interpret test results and further selection of cancer therapy, a consultation with a clinical geneticist, an oncologist is required.

This method allows to read hundreds of millions of short DNA sequences concurrently and to identify all types of mutations, including

1. Technique sensitivity and specificity
2. Fast execution time
3. Concurrent identification of all types of mutations, including structural rearrangements
4. Minimum requirements for the quantity and quality of samples
5. Reducing time of analysis